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KMID : 0438419960030020149
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Korean Journal of Bone Metabolism
1996 Volume.3 No. 2 p.149 ~ p.156
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Assessment of Bone Density with pQCT
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Abstract
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In vivo short-term precision of pQCT and comparison to DXA bone densitometry was performed in 60 wornen(20; healthy premenopasual, 20; postmenopausal, 20; postmenopausal:with osteoporosis defined by simple x-ray). Subjects were measured repeatedly for 10 times with pQCT and calculated CV(%) to determine the pricision. pQCT and DXA. were also compared in 170 women grouped as A; healthy premenopausal women(44 subjects), B; healthy postmenopausal women(100 subjects) and C; osteoporotic postmenopausal women. All subjects were asked to measure their skeletal status by both machines simultaneously. pQCT precision error was lowest in healthy premenopausal women and highest in healthy postmenopausal women. The total and trabecular compartmental volumetric bone density measured in healthy pre and postmenopausal women were significantly higher than that of osteoporotic postmenopausal women whereas the cortical bone did not show significant difference between the two groups due to large precision error. Of the three compartmental bone density measured by pQCT osteoporotic postmenopausal women had lost 45% of the trabecular bone from the estimated peak bone density. The relationship between the bone densities measured by two different bone densitometries had moderate correlation and this correlation coefficient became larger when their age was adjusted. The healthy women would have 53% of trabecular bone in the ultradistal part of radius and the rest may be the cortical bone. According to pQCT healthy premenopausal women will be estimated to lose 0.1%/yr trabecular bone and 0.66%/yr of total bone and healthy post-menopausal women will be estimated to lose 1.4%/yr of both trabecular and total bone. These parameters yield that the compartmental measurement of bone density with pQCT may be a good predictor of assessing future fracture risk and this study indicate its usefulness in diagnosing postmenopausal osteoporosis.
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KEYWORD
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